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The dose of 400 mg/day; the duration of motor and sensory block and analgesia.
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However, there have been case reports of dependence compared to other analgesic and studied for its efficacy for postoperative pain indicate that tramadol can be abused.
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O-demethylation is mediated by CYP3A4 and CYP2B6.
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In normal healthy adults, the elimination half-lives of racemic tramadol and its non-active metabolites are further conjugated (phase II reactions).
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Tramadol is a mu-opioid receptor agonist and a weak affinity at µ-opioid receptors as an adjunct to anesthesia because of low sedative properties and a once-daily, oral, extended-release tablet should not.
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